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  1. Research article

    Toxicology evaluation of radiotracer doses of 3'-deoxy-3'-[18F]fluorothymidine (18F-FLT) for human PET imaging: Laboratory analysis of serial blood samples and comparison to previously investigated therapeutic FLT doses

    18F-FLT is a novel PET radiotracer which has demonstrated a strong potential utility for imaging cellular proliferation in human tumors in vivo. To facilitate future regulatory approval of 18F-FLT for clinical u...

    Eric Turcotte, Linda W Wiens, John R Grierson, Lanell M Peterson, Mark H Wener and Hubert Vesselle

    BMC Nuclear Medicine 2007 7:3

    Published on: 3 July 2007

  2. Technical advance

    Comparison of manual and semi-automated delineation of regions of interest for radioligand PET imaging analysis

    As imaging centers produce higher resolution research scans, the number of man-hours required to process regional data has become a major concern. Comparison of automated vs. manual methodology has not been re...

    Tiffany W Chow, Shinichiro Takeshita, Kie Honjo, Christina E Pataky, Peggy L St Jacques, Maggie L Kusano, Curtis B Caldwell, Joel Ramirez, Sandra Black and Nicolaas PLG Verhoeff

    BMC Nuclear Medicine 2007 7:2

    Published on: 29 January 2007

  3. Research article

    A statistical investigation of normal regional intra-subject heterogeneity of brain metabolism and perfusion by F-18 FDG and O-15 H2O PET imaging

    The definite evaluation of the regional cerebral heterogeneity using perfusion and metabolism by a single modality of PET imaging has not been well addressed. Thus a statistical analysis of voxel variables fro...

    Ching-yee Oliver Wong, Joseph Thie, Marianne Gaskill, Richard Ponto, Jack Hill, Hai-yan Tian, Helena Balon, Dafang Wu, Darlene Fink-Bennett and Conrad Nagle

    BMC Nuclear Medicine 2006 6:4

    Published on: 12 July 2006

  4. Research article

    Non-invasive imaging of atherosclerotic plaque macrophage in a rabbit model with F-18 FDG PET: a histopathological correlation

    Coronary atherosclerosis and its thrombotic complications are the major cause of mortality and morbidity throughout the industrialized world. Thrombosis on disrupted atherosclerotic plaques plays a key role in...

    Zhuangyu Zhang, Josef Machac, Gerard Helft, Stephen G Worthley, Cheuk Tang, Azfar G Zaman, Oswaldo J Rodriguez, Monte S Buchsbaum, Valentin Fuster and Juan J Badimon

    BMC Nuclear Medicine 2006 6:3

    Published on: 25 May 2006

  5. Research article

    Prognostic utility of sestamibi lung uptake does not require adjustment for stress-related variables: A retrospective cohort study

    Increased 99mTc-sestamibi stress lung-to-heart ratio (sLHR) has been shown to predict cardiac outcomes similar to pulmonary uptake of thallium. Peak heart rate and use of pharmacologic stress affect the interpret...

    William D Leslie, Marina S Yogendran, Linda M Ward, Khaled A Nour and Colleen J Metge

    BMC Nuclear Medicine 2006 6:2

    Published on: 29 March 2006

  6. Research article

    Frequency and severity of myocardial perfusion abnormalities using Tc-99m MIBI SPECT in cardiac syndrome X

    Cardiac syndrome X is defined by a typical angina pectoris with normal or near normal (stenosis <40%) coronary angiogram with or without electrocardiogram (ECG) change or atypical angina pectoris with normal o...

    Mohsen Saghari, Majid Assadi, Mohammad Eftekhari, Mohammad Yaghoubi, Armaghan Fard-Esfahani, Jan-Mohammad Malekzadeh, Babak Fallhi Sichani, Davood Beiki and Abbas Takavar

    BMC Nuclear Medicine 2006 6:1

    Published on: 17 February 2006

  7. Research article

    Relationship of 99mtechnetium labelled macroaggregated albumin (99mTc-MAA) uptake by colorectal liver metastases to response following Selective Internal Radiation Therapy (SIRT)

    SIRT is an emerging treatment for liver tumours which relies on the selective uptake by tumour of 90Y microspheres following hepatic arterial injection. Response rates of around 90% are reported. Hepatic arterial...

    Atul Dhabuwala, Prue Lamerton and Richard S Stubbs

    BMC Nuclear Medicine 2005 5:7

    Published on: 23 December 2005

  8. Research article

    A preliminary study of neuroSPECT evaluation of patients with post-traumatic smell impairment

    Most olfactory testings are subjective and since they depend upon the patients' response, they are prone to false positive results. The aim of this study was to use quantitative brain perfusion SPECT in order ...

    Mohammad Eftekhari, Majid Assadi, Majid Kazemi, Mohsen Saghari, Armaghan Fard Esfahani, Babak Fallahi Sichani, Ali Gholamrezanezhad and Davood Beiki

    BMC Nuclear Medicine 2005 5:6

    Published on: 28 November 2005

  9. Research article

    Planar Tc99m – sestamibi scintimammography should be considered cautiously in the axillary evaluation of breast cancer protocols: Results of an international multicenter trial

    Lymph node status is the most important prognostic indicator in breast cancer in recently diagnosed primary lesion. As a part of an interregional protocol using scintimammography with Tc99m compounds, the valu...

    Teresa Massardo, Omar Alonso, Augusto Llamas-Ollier, Levin Kabasakal, Uma Ravishankar, Rossana Morales, Lucía Delgado and Ajit K Padhy

    BMC Nuclear Medicine 2005 5:4

    Published on: 27 July 2005

  10. Research article

    Comparison of SPECT bone scintigraphy with MRI for diagnosis of meniscal tears

    Scintigraphy has been considered as competitive to MRI, but limited data are available on the accuracy of single photon emission tomography (SPECT) compared with MRI for the assessment of meniscal tears. Our o...

    Mohammad-naghi Tahmasebi, Mohsen Saghari, Masoud Moslehi and Ali Gholamrezanezhad

    BMC Nuclear Medicine 2005 5:2

    Published on: 14 April 2005

  11. Research article

    Sodium pertechnetate (Na99mTcO4) biodistribution in mice exposed to cigarette smoke

    The biological effects of cigarette smoke are not fully known. To improve our understanding of the action of various chemical agents, we investigated the biodistribution of sodium pertechnetate (Na99mTcO4) in mic...

    Samuel S Valenca, Elaine AC Lima, Gláucio F Dire, Mário Bernardo-Filho and Luís Cristóvão Porto

    BMC Nuclear Medicine 2005 5:1

    Published on: 11 April 2005

  12. Research article

    Evaluation of the clinical value of bone metabolic parameters for the screening of osseous metastases compared to bone scintigraphy

    Bone metastases are common in many types of cancer. As screening methods different imaging modalities are available. A new approach for the screening of osseous metastases represents the measurement of bone me...

    Johann Schoenberger, Silke Rozeboom, Eva Wirthgen-Beyer and Christoph Eilles

    BMC Nuclear Medicine 2004 4:3

    Published on: 4 December 2004

  13. Research article

    188Re radiopharmaceuticals for radiosynovectomy: evaluation and comparison of tin colloid, hydroxyapatite and tin-ferric hydroxide macroaggregates

    Radiosynovectomy is a therapy used to relieve pain and inflammation from rheumatoid arthritis and related diseases. In this study three 188Re particulate compounds were characterized according to their physico-ch...

    Eduardo Savio, María Cristina Ures, Patricia Zeledón, Victoria Trindade, Andrea Paolino, Virginia Mockford, Antonio Malanga, Marcelo Fernández and Javier Gaudiano

    BMC Nuclear Medicine 2004 4:1

    Published on: 30 January 2004

  14. Research article

    Comparison of Technetium-99m-MIBI imaging with MRI for detection of spine involvement in patients with multiple myeloma

    Recently, radiopharmaceutical scanning with Tc-99m-MIBI was reported to depict areas with active bone disease in multiple myeloma (MM) with both high sensitivity and specificity. This observation was explained...

    Siroos Mirzaei, Martin Filipits, Andrea Keck, Walter Bergmayer, Peter Knoll, Horst Koehn, Heinz Ludwig and Martin Pecherstorfer

    BMC Nuclear Medicine 2003 3:2

    Published on: 11 December 2003

  15. Research article

    Physico-chemical characterisation and biological evaluation of 188-Rhenium colloids for radiosynovectomy

    Radiosynovectomy is a type of radiotherapy used to relieve pain and inflammation from rheumatoid arthritis. In this study, 188-Rhenium (188Re) colloids were characterized by physical and biological methodologies....

    Ma Cristina Ures, Eduardo Savio, Antonio Malanga, Marcelo Fernández, Andrea Paolino and Javier Gaudiano

    BMC Nuclear Medicine 2002 2:1

    Published on: 14 October 2002

  16. Research article

    Re-HEDP : pharmacokinetic characterization, clinical and dosimetric evaluation in osseous metastatic patients with two levels of radiopharmaceutical dose

    A study for pain relief therapy with 188Re-HEDP was done in patients with bone metastases secondary to breast and prostate cancer.

    Eduardo Savio, Javier Gaudiano, Ana M Robles, Henia Balter, Andrea Paolino, Andrea López, Juan C Hermida, Eugenia De Marco, Graciela Martinez, Eduardo Osinaga and Furn F Knapp

    BMC Nuclear Medicine 2001 1:2

    Published on: 21 November 2001

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