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Table 1 The dose and outcome ranges for optimized therapy

From: A mathematical model of optimized radioiodine-131 therapy of Graves' hyperthyroidism

Method

Outcome

 

Dose range

Cure%

Euthy%

Hypo%

 

(min/max)

(min/max)

(peak/min)

(min/max)

 

Non-ablative

AbsD

70Gy

58%

48%

10%

 

140Gy

76%

38%

38%

FixA

180 MBq

70%

46%

24%

 

310 MBq

82%

41%

41%

 

Ablative

CalA

~ 11.4 MBq/g

91%

1%

90%

  1. The data is based on a combination of both models described in the text and depicted in figure 1. Minimum and maximum doses apply only to nonablative regimens. The minimum dose is at peak euthyroid rates. The maximum dose is where hypothyroid rates have caught up to euthyroid rates (making up half of the cure rates). The non-ablative cure range is 60–80% and the FixA gives superior results for cure > 70%.
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BMC Medical Physics

ISSN: 1756-6649