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Table 1 In vitro dissolution and disintegration constants (p 0.05)

From: Hydrophilic and lipophilic radiopharmaceuticals as tracers in pharmaceutical development: In vitroIn vivo studies

Radiopharmaceutical

Dissolution velocity Constant (min-1) (n = 6)

Disintegration velocity Constant (min-1) (n = 6)

99mTc-MIBI

(0.05 ± 0.02) all pH range

(0.04 ± 0.01) all pH range

99mTc-ECD

(0.040 ± 0.005) all pH range

(0.05 ± 0.01) (pH 1)

(0.09 ± 0.01) (pH4 and 7)

99mTc-MDP

(0.020 ± 0.005) all pH range

(0.20 ± 0.04) (pH 1 and 7)

(0.040 ± 0.005) (pH 4)

99mTc-DTPA

(0.06 ± 0.01) (pH1and 7)

(0.11 ± 0.02) (pH 4)

0.011 ± 0.002 (pH1and 7)

0.080 ± 0.006 (pH 4)