Comparison of manual and semi-automated delineation of regions of interest for radioligand PET imaging analysis

BMC Medical Physics

Table 2 Correlations between 5-HT1aR BP values from manual versus SABRE ROI analysis (Spearman r_s values) were statistically significant (p < .05) except where noted.

	S1A vs M1A		S1A vs M1B		S1A vs M2		Row Average
	Lt	Rt	Lt	Rt	Lt	Rt	Lt	Rt
Frontal lobe	0.80	0.93	0.90	0.88	0.75	0.97	0.82	0.93
OFC	0.82	0.93	0.83	0.93	0.78	0.87	0.81	0.91
DLPFC	0.87	0.88	0.88	0.78	0.85	0.67	0.87	0.78
Ant. Lat. Temporal lobe	0.95	0.90	0.93	0.82	0.63	0.67	0.84	0.79
Medial Temporal	0.58	0.85	0.60	0.80	0.68	0.52†	0.62	0.72
Column Average	0.80	0.90	0.83	0.84	0.74	0.74	0.79	0.83
	S1B vs M1A		S1B vs M1B		S1B vs M2
	Lt	Rt	Lt	Rt	Lt	Rt
Frontal lobe	0.82	0.90	0.95	0.85	0.75	0.95	0.84	0.90
OFC	0.82	0.80	0.83	0.80	0.78	0.88	0.81	0.83
DLPFC	0.92	0.85	0.93	0.85	0.88	0.78	0.91	0.83
Ant. Lat. Temporal lobe	0.90	0.95	0.88	0.87	0.70	0.53†	0.83	0.78
Medial Temporal	0.42†	0.85	0.33†	0.83	0.50†	0.72	0.42	0.80
Column Average	0.77	0.87	0.79	0.84	0.72	0.77	0.76	0.83
	S2 vs M1A		S2 vs M1B		S2 vs M2
	Lt	Rt	Lt	Rt	Lt	Rt
Frontal lobe	0.80	0.93	0.90	0.88	0.75	0.97	0.82	0.93
OFC	0.97	0.80	0.98	0.80	0.93	0.88	0.96	0.83
DLPFC	0.88	0.72	0.78	0.72	0.83	0.92	0.83	0.78
Ant. Lat. Temporal lobe	0.98	0.95	0.92	0.92	0.65	0.43†	0.85	0.77
Medial Temporal	0.37†	0.85	0.33†	0.83	0.47†	0.72	0.39	0.80
Column Average	0.80	0.85	0.78	0.83	0.73	0.78	0.77	0.82