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Table 1 Difference between experimental curve and target curve for all performed studies according to three pre-specified criteria.

From: A computerized Infusion Pump for control of tissue tracer concentration during Positron Emission Tomography in vivoPharmacokinetic/Pharmacodynamic measurements

Target curve

AUCdiff(%)

MAXdev(%)*

R2

Comment

Steady state (n = 3)

1.0

9.6

0.92

Figure 3a

Step function (n = 3)

6.3

12.2

0.96

Figure 3b

Oral adm. 1

4.2

8.7

0.98

Figure 3c

Oral adm. 2

1.7

20.3

0.95

Figure 3d

Oral adm. 3

7.6

17.2

0.96

Figure 3e

Average ± stdev

4.2 ± 2.8

13.6 ± 5.0

0.95 ± 0.02

 
  1. *At very low concentrations (beginning of scans) even small actual errors gives very large percentual errors. The MAXdev is therefore calculated from data points >15 minutes into the scan.
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BMC Medical Physics

ISSN: 1756-6649