Tissue dielectric properties are specific to physiological changes and consequently have been pursued as imaging biomarkers of cancer and other pathological disorders. However, a recent study (Phys Med Biol 52...
Authors: Paul M Meaney, Andrew P Gregory, Neil R Epstein and Keith D Paulsen
Fractal geometry has been the basis for the development of a diagnosis of preneoplastic and neoplastic cells that clears up the undetermination of the atypical squamous cells of undetermined significance (ASCUS).
Authors: Signed E Prieto Bohórquez, Javier O Rodríguez Velásquez, S Catalina Correa Herrera and M Yolanda Soracipa Muñoz
Few studies to date have directly compared the Actigraphs GT1M and the GT3X, it would be of tremendous value to know if these accelerometers give similar information about intensities of PA. Knowing if output ...
Authors: Louise A Kelly, Duncan GE McMillan, Alexandra Anderson, Morgan Fippinger, Gunnar Fillerup and Jane Rider
The rapid adoption of image-guidance in prostate intensity-modulated radiotherapy (IMRT) results in longer treatment times, which may result in larger intrafraction motion, thereby negating the advantage of im...
Authors: Avilash K Cramer, Amanu G Haile, Sanja Ognjenovic, Tulsee S Doshi, William Matthew Reilly, Katherine E Rubinstein, Nima Nabavizadeh, Thuan Nguyen, Lu Z Meng, Martin Fuss, James A Tanyi and Arthur Y Hung
HIV diagnosis, prognostic and treatment requires T CD4 lymphocytes’ number from flow cytometry, an expensive technique often not available to people in developing countries. The aim of this work is to apply a ...
Authors: Javier O Rodríguez, Signed E Prieto, Catalina Correa, Carlos E Pérez, Jessica T Mora, Juan Bravo, Yolanda Soracipa and Luisa F Álvarez
Calculation of accumulated dose in fractionated radiotherapy based on spatial mapping of the dose points generally requires deformable image registration (DIR). The accuracy of the accumulated dose thus depend...
Authors: David Tilly, Nina Tilly and Anders Ahnesjö
In this paper we apply the principal-component analysis filter (Hotelling filter) to reduce noise from dynamic positron-emission tomography (PET) patient data, for a number of different radio-tracer molecules....
Analyzing and monitoring uterine contractions during pregnancy is relevant to the field of reproductive health assessment. Its clinical importance is grounded in the need to reliably predict the onset of labor...
Authors: Patricio S La Rosa, Hari Eswaran, Hubert Preissl and Arye Nehorai
Radiosensitivity is an inheriting trait that mainly depends on genetic factors. it is well known in similar dose of ionizing radiation and identical biological characteristics 9–10 percent of normal population...
Authors: Meysam Khosravifarsani, Ali Shabestani Monfared, Haleh Akhavan-Niaki, Dariush Moslemi, Karimollah Hajian-Tilaki, Farideh Elahimanesh, Sajad Borzoueisileh, Nayer Seyfizadeh and Mehrangiz Amiri
Intensity modulated radiotherapy is an efficient radiotherapy technique to increase dose in target volumes and decrease irradiation dose in organs at risk. This last objective is mainly relevant in children. H...
Authors: Violaine Beneyton, Claudine Niederst, Céline Vigneron, Philippe Meyer, François Becmeur, Luc Marcellin, Patrick Lutz and Georges Noel
Biologically-based models that utilize 3D radiation dosimetry data to estimate the risk of late cardiac effects could have significant utility for planning radiotherapy in young patients. A major challenge ari...
Authors: Angela Ng, Thao-Nguyen Nguyen, Joanne L Moseley, David C Hodgson, Michael B Sharpe and Kristy K Brock
Evaluation of changes in tumor size from images acquired by ultrasound (US), computed tomography (CT) or magnetic resonance imaging (MRI) is a common measure of cancer chemotherapy efficacy. Tumor size measure...
Authors: Yongsook C Lee, Gary D Fullerton, Cristel Baiu, Margaret G Lescrenier and Beth A Goins
Fractal geometry is employ to characterize the irregular objects and had been used in experimental and clinic applications. Starting from a previous work, here we made a theoretical research based on a geometr...
Authors: Javier O Rodríguez, Signed E Prieto, Catalina Correa, Pedro A Bernal, Germán E Puerta, Sarith Vitery, Yolanda Soracipa and Diana Muñoz
Radiation-induced chromosome aberrations lead to a plethora of detrimental effects at cellular level. Chromosome aberrations provide broad spectrum of information ranging from probability of malignant transfor...
Authors: Rupak Pathak, Adarsh Ramakumar, Uma Subramanian and Pataje GS Prasanna
Light chain amyloidosis (AL) is a rare plasma cell dyscrasia associated with poor survival especially in the setting of heart failure. Late gadolinium enhancement (LGE) on cardiac MRI was recently found to cor...
Authors: Raymond Q Migrino, Richard Christenson, Aniko Szabo, Megan Bright, Seth Truran and Parameswaran Hari
The present study determines the feasibility of generating an average arterial input function (Avg-AIF) from a limited population of patients with neck nodal metastases to be used for pharmacokinetic modeling ...
Authors: Amita Shukla-Dave, Nancy Lee, Hilda Stambuk, Ya Wang, Wei Huang, Howard T Thaler, Snehal G Patel, Jatin P Shah and Jason A Koutcher
Skeletal uptake of 99mTc labelled methylene diphosphonate (99mTc-MDP) is used for producing images of pathological bone uptake due to its incorporation to the sites of active bone turnover. This study was done to...
Authors: Janaka Lenora, Kristina Norrgren, Ola Thorsson, Per Wollmer, Karl J Obrant and Kaisa K Ivaska
We evaluated the repeatability of the calculation of myocardial blood flow (MBF) at rest and pharmacological stress, and calculated the coronary flow reserve (CFR) utilizing 82Rb PET imaging. The aim of the resea...
Authors: Karin Knešaurek, Josef Machac and Zhuangyu Zhang
The present study explores the efficacy and toxicity of combining a new, non-toxic, cancer treatment modality, termed Tumor Treating Fields (TTFields), with chemotherapeutic treatment in-vitro, in-vivo and in ...
Authors: Eilon D Kirson, Rosa S Schneiderman, Vladimír Dbalý, František Tovaryš, Josef Vymazal, Aviran Itzhaki, Daniel Mordechovich, Zoya Gurvich, Esther Shmueli, Dorit Goldsher, Yoram Wasserman and Yoram Palti
The accuracy of multiple window spatial resolution characterises the performance of a gamma camera for dual isotope imaging. In the present study we investigate an alternative method to the standard NEMA proce...
Authors: Helmar Bergmann, Gregory Minear, Maria Raith and Peter M Schaffarich
Breathing motion should be considered for stereotactic body radiotherapy (SBRT) of lung tumors. Four-dimensional computer tomography (4D-CT) offers detailed information of tumor motion. The aim of this work is...
Authors: Anne Richter, Kurt Baier, Juergen Meyer, Juergen Wilbert, Thomas Krieger, Michael Flentje and Matthias Guckenberger
Several fluorine-18 labelled fluoroamino acids have been evaluated as tracers for the quantitative assessment of cerebral protein synthesis in vivo by positron emission tomography (PET). Among these, 2-[18F]fluor...
Authors: Joël J Aerts, Alain R Plenevaux, Christian F Lemaire, Fabrice Giacomelli, Geoffrey I Warnock, Christophe L Phillips and André J Luxen
Surgical resection is the preferred treatment of potentially curable esophageal cancer. To improve long term patient outcome, many institutes apply neoadjuvant chemoradiotherapy. In a large proportion of patie...
Authors: Mark van Heijl, Jikke MT Omloo, Mark I van Berge Henegouwen, Olivier RC Busch, Hugo W Tilanus, Patrick MM Bossuyt, Otto S Hoekstra, Jaap Stoker, Maarten CCM Hulshof, Ate van der Gaast, Grard AP Nieuwenhuijzen, Han J Bonenkamp, John ThM Plukker, Ernst J Spillenaar Bilgen, Fibo JW ten Kate, Ronald Boellaard…
A computer controlled infusion pump (UIPump) for regulation of target tissue concentration of radioactive compounds was developed for use in biological research and tracer development for PET.
Authors: Olof Eriksson, Andreas Wallberg, Stina Syvänen, Raymond Josephsson, Bengt Långström and Mats Bergström
99mTc-HMPAO is a well-established isotope useful in the detection of regional cerebral blood flow. Diabetes gives rise to arterial atherosclerotic changes that can lead to significant end organ dysfunction, prom...
We compared 2D, 3D high dose (HD) and 3D low dose (LD) gated myocardial Rb-82 PET imaging in 16 normal human studies. The main goal in the paper is to evaluate whether the images obtained by a 3D LD studies ar...
Authors: Karin Knešaurek, Josef Machac and Jong Ho Kim
18F-FLT is a novel PET radiotracer which has demonstrated a strong potential utility for imaging cellular proliferation in human tumors in vivo. To facilitate future regulatory approval of 18F-FLT for clinical u...
Authors: Eric Turcotte, Linda W Wiens, John R Grierson, Lanell M Peterson, Mark H Wener and Hubert Vesselle
As imaging centers produce higher resolution research scans, the number of man-hours required to process regional data has become a major concern. Comparison of automated vs. manual methodology has not been re...
Authors: Tiffany W Chow, Shinichiro Takeshita, Kie Honjo, Christina E Pataky, Peggy L St Jacques, Maggie L Kusano, Curtis B Caldwell, Joel Ramirez, Sandra Black and Nicolaas PLG Verhoeff
Transient arrhythmias can affect transient ischemic dilation (TID) ratios. This study was initiated to evaluate the frequency and effect of normal heart rate change on TID measures in routine clinical practice.
Authors: William D Leslie, Daniel P Levin and Sandor J Demeter
Positron emission tomography (PET) imaging with fluorine-18 (18F) Fluorodeoxyglucose (FDG) and flow tracer such as Rubidium-82 (82Rb) is an established method for evaluating an ischemic but viable myocardium. How...
The definite evaluation of the regional cerebral heterogeneity using perfusion and metabolism by a single modality of PET imaging has not been well addressed. Thus a statistical analysis of voxel variables fro...
Authors: Ching-yee Oliver Wong, Joseph Thie, Marianne Gaskill, Richard Ponto, Jack Hill, Hai-yan Tian, Helena Balon, Dafang Wu, Darlene Fink-Bennett and Conrad Nagle
Coronary atherosclerosis and its thrombotic complications are the major cause of mortality and morbidity throughout the industrialized world. Thrombosis on disrupted atherosclerotic plaques plays a key role in...
Authors: Zhuangyu Zhang, Josef Machac, Gerard Helft, Stephen G Worthley, Cheuk Tang, Azfar G Zaman, Oswaldo J Rodriguez, Monte S Buchsbaum, Valentin Fuster and Juan J Badimon
Increased 99mTc-sestamibi stress lung-to-heart ratio (sLHR) has been shown to predict cardiac outcomes similar to pulmonary uptake of thallium. Peak heart rate and use of pharmacologic stress affect the interpret...
Authors: William D Leslie, Marina S Yogendran, Linda M Ward, Khaled A Nour and Colleen J Metge
Cardiac syndrome X is defined by a typical angina pectoris with normal or near normal (stenosis <40%) coronary angiogram with or without electrocardiogram (ECG) change or atypical angina pectoris with normal o...
Authors: Mohsen Saghari, Majid Assadi, Mohammad Eftekhari, Mohammad Yaghoubi, Armaghan Fard-Esfahani, Jan-Mohammad Malekzadeh, Babak Fallhi Sichani, Davood Beiki and Abbas Takavar
SIRT is an emerging treatment for liver tumours which relies on the selective uptake by tumour of 90Y microspheres following hepatic arterial injection. Response rates of around 90% are reported. Hepatic arterial...
Authors: Atul Dhabuwala, Prue Lamerton and Richard S Stubbs
Most olfactory testings are subjective and since they depend upon the patients' response, they are prone to false positive results. The aim of this study was to use quantitative brain perfusion SPECT in order ...
Authors: Mohammad Eftekhari, Majid Assadi, Majid Kazemi, Mohsen Saghari, Armaghan Fard Esfahani, Babak Fallahi Sichani, Ali Gholamrezanezhad and Davood Beiki
Scintigraphic studies have been performed to assess the release, both in vitro and in vivo, of radiotracers from tablet formulations. Four different tracers with differing physicochemical characteristics have bee...
Authors: Mariella Terán, Eduardo Savio, Andrea Paolino and Malcolm Frier
Lymph node status is the most important prognostic indicator in breast cancer in recently diagnosed primary lesion. As a part of an interregional protocol using scintimammography with Tc99m compounds, the valu...
Authors: Teresa Massardo, Omar Alonso, Augusto Llamas-Ollier, Levin Kabasakal, Uma Ravishankar, Rossana Morales, Lucía Delgado and Ajit K Padhy
Attenuation correction is generally used to PET images to achieve count rate values independent from tissue densities. The goal of this study was to provide a qualitative comparison of attenuation corrected PE...
Authors: Siroos Mirzaei, Michel Guerchaft, Christopher Bonnier, Peter Knoll, Michel Doat and Peter Braeutigam
Scintigraphy has been considered as competitive to MRI, but limited data are available on the accuracy of single photon emission tomography (SPECT) compared with MRI for the assessment of meniscal tears. Our o...
Authors: Mohammad-naghi Tahmasebi, Mohsen Saghari, Masoud Moslehi and Ali Gholamrezanezhad
The biological effects of cigarette smoke are not fully known. To improve our understanding of the action of various chemical agents, we investigated the biodistribution of sodium pertechnetate (Na99mTcO4) in mic...
Authors: Samuel S Valenca, Elaine AC Lima, Gláucio F Dire, Mário Bernardo-Filho and Luís Cristóvão Porto
Bone metastases are common in many types of cancer. As screening methods different imaging modalities are available. A new approach for the screening of osseous metastases represents the measurement of bone me...
Authors: Johann Schoenberger, Silke Rozeboom, Eva Wirthgen-Beyer and Christoph Eilles
Single photon emission computed tomography (SPECT) following injection of radiotracer during a seizure is known as ictal SPECT. Comparison of an ictal SPECT study to a baseline or interictal study can aid iden...
Authors: Tracy Butler, Lawrence J Hirsch and Jan Claassen
Radiosynovectomy is a therapy used to relieve pain and inflammation from rheumatoid arthritis and related diseases. In this study three 188Re particulate compounds were characterized according to their physico-ch...
Authors: Eduardo Savio, María Cristina Ures, Patricia Zeledón, Victoria Trindade, Andrea Paolino, Virginia Mockford, Antonio Malanga, Marcelo Fernández and Javier Gaudiano
Recently, radiopharmaceutical scanning with Tc-99m-MIBI was reported to depict areas with active bone disease in multiple myeloma (MM) with both high sensitivity and specificity. This observation was explained...
Authors: Siroos Mirzaei, Martin Filipits, Andrea Keck, Walter Bergmayer, Peter Knoll, Horst Koehn, Heinz Ludwig and Martin Pecherstorfer
Lewy body disease is, after Alzheimer's disease, the second most common cause of senile degenerative dementia with progressive cognitive deterioration, fluctuation of cognitive and motoric functions and psycho...
Authors: Siroos Mirzaei, Peter Knoll, Horst Koehn and Thomas Bruecke
Radiosynovectomy is a type of radiotherapy used to relieve pain and inflammation from rheumatoid arthritis. In this study, 188-Rhenium (188Re) colloids were characterized by physical and biological methodologies....
Authors: Ma Cristina Ures, Eduardo Savio, Antonio Malanga, Marcelo Fernández, Andrea Paolino and Javier Gaudiano
A study for pain relief therapy with 188Re-HEDP was done in patients with bone metastases secondary to breast and prostate cancer.
Authors: Eduardo Savio, Javier Gaudiano, Ana M Robles, Henia Balter, Andrea Paolino, Andrea López, Juan C Hermida, Eugenia De Marco, Graciela Martinez, Eduardo Osinaga and Furn F Knapp Jr
